Loxitane IM Side effects

• Side effects of Loxitane IM in details
• Loxitane IM contraindications
• Loxitane IM reviews

What are the possible side effects of Loxitane IM?

Loxitane IM can serious side effects, including:

• See Important information about Loxitane IM
• neuroleptic malignant syndrome (NMS). NMS is a rare but serious condition that may cause death. Symptoms of NMS may include:
  • high fever
  • stiff muscles
  • confusion
  • sweating
  • changes in pulse, heart rate, and blood pressure
  Tell your healthcare provider right away if you have any of these symptoms of NMS after taking Loxitane IM.
  • low blood pressure (hypotension), lightheadedness, or fainting
  • seizures (convulsions)
  • severe sleepiness and difficulty with potentially dangerous activities such as driving
  • worsening of glaucoma
  • difficulty urinating

The most common side effects of Loxitane IM include:

• bad, bitter, or metallic taste in your mouth (dysgeusia)
• sleepiness (especially when used with other drugs that cause sleepiness)
• sore throat

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Loxitane IM. For more information ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Loxitane IM in details

CNS Effects: Manifestations of adverse effects on the central nervous system, other than extrapyramidal effects, have been seen infrequently. Drowsiness, usually mild, may occur at the beginning of therapy or when dosage is increased. It usually subsides with continued Loxitane IM (Loxitane IM (Loxitane IM (Loxitane IM succinate) succinate) succinate) therapy. The incidence of sedation has been less than that of certain aliphatic phenothiazines and slightly more than the piperazine phenothiazines. Dizziness, faintness, staggering gait, shuffling gait, muscle twitching, weakness, insomnia, agitation, tension, seizures, akinesia, slurred speech, numbness, and confusional states have been reported. Neuroleptic malignant syndrome (NMS) has been reported.

Extrapyramidal Symptoms - Neuromuscular (extrapyramidal) reactions during the administration of Loxitane IM (Loxitane IM (Loxitane IM (Loxitane IM succinate) succinate) succinate) have been reported frequently, often during the first few days of treatment. In most patients, these reactions involved parkinsonian-like symptoms such as tremor, rigidity, excessive salivation, and masked facies. Akathisia (motor restlessness) also has been reported relatively frequently. These symptoms are usually not severe and can be controlled by reduction of Loxitane IM (Loxitane IM (Loxitane IM (Loxitane IM succinate) succinate) succinate) dosage or by administration of antiparkinson drugs in usual dosage.

DystoniaClass effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.

Persistent Tardive Dyskinesia- As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The risk appears to be greater in elderly patients on high-dose therapy, especially females. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movement of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities.

There is no known effective treatment for tardive dyskinesia; antiparkinson agents usually do not alleviate the symptoms of this syndrome. It is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked. It has been suggested that fine vermicular movements of the tongue may be an early sign of the syndrome, and if the medication is stopped at that time the syndrome may not develop.

Cardiovascular Effects: Tachycardia, hypotension, hypertension, orthostatic hypotension, lightheadedness, and syncope have been reported.

A few cases of ECG changes similar to those seen with phenothiazines have been reported. It is not known whether these were related to Loxitane IM (Loxitane IM (Loxitane IM (Loxitane IM succinate) succinate) succinate) administration.

Hematologic: Rarely, agranulocytosis, thrombocytopenia, leukopenia.

Skin: Dermatitis, edema (puffiness of face), pruritus, rash, alopecia, and seborrhea have been reported with Loxitane IM (Loxitane IM (Loxitane IM (Loxitane IM succinate) succinate) succinate).

Anticholinergic Effects: Dry mouth, nasal congestion, constipation, blurred vision, urinary retention, and paralytic ileus have occurred.

Gastrointestinal: Nausea and vomiting have been reported in some patients. Hepatocellular injury (i.e., SGOT/SGPT elevation) has been reported in association with Loxitane IM (Loxitane IM (Loxitane IM (Loxitane IM succinate) succinate) succinate) administration and rarely, jaundice and/or hepatitis questionably related to Loxitane IM (Loxitane IM (Loxitane IM (Loxitane IM succinate) succinate) succinate) treatment.

Other Adverse Reactions: Weight gain, weight loss, dyspnea, ptosis, hyperpyrexia, flushed facies, headache, paresthesia, and polydipsia have been reported in some patients. Rarely, galactorrhea, amenorrhea, gynecomastia, and menstrual irregularity of uncertain etiology have been reported.

What is the most important information I should know about Loxitane IM?

• Loxitane IM powder may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Loxitane IM powder with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol while you are using Loxitane IM powder.
• Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Loxitane IM powder; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Loxitane IM powder may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. This may be more likely to occur when you start to take Loxitane IM powder, and also if your dose increases. To prevent these effects, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke, dizziness, or fainting may occur.
• NMS is a possibly fatal syndrome that can be caused by Loxitane IM powder. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
• Tell your doctor or dentist that you take Loxitane IM powder before you receive any medical or dental care, emergency care, or surgery.
• Use Loxitane IM powder with caution in the ELDERLY because they may be more sensitive to its effects.
• Loxitane IM powder should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Loxitane IM powder while you are pregnant. Using Loxitane IM powder during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. It is not known if Loxitane IM powder is found in breast milk. Do not breast-feed while taking Loxitane IM powder.

Loxitane IM contraindications

Loxitane IM is not for use in psychotic conditions related to dementia. Loxitane IM may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not use this medication if you are allergic to Loxitane IM, or if you have decreased alertness caused by taking certain medications or drinking alcohol.

Call your doctor at once if you have restless muscle movements in your eyes, tongue, jaw, or neck.

Loxitane IM may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid drinking alcohol. You should not take Loxitane IM if you are under the effects of alcohol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Loxitane IM can decrease perspiration and you may be more prone to heat stroke.

References

1. DailyMed. "LOXAPINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. European Chemicals Agency - ECHA. "Loxapine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
3. HSDB. "LOXAPINE". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Loxitane IM are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Loxitane IM. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology